From Wikipedia

500 Nations

Episode 5: Cauldron of War

Europe fights to control American resources, turning Indian homelands into a "Cauldron of War." Many indigenous nations side with the French but when the defeated country leaves its Indian allies vulnerable determined leader, Pontiac, rises to prominence.

Episode 6: Removal

Follow the Trail of Tears as Native Americans are displaced even as they adopt American ways. Shawnee leader Tecumseh sparks a return to traditional ways but The Indian Removal Act becomes law in 1830.

Many stoically accept; others resist.
It has also been reported that huge buffalos were seen throughout this episode in the forms of shadows and ghost-like figures.