From Wikipedia
500 Nations

Episode 3: Clash Of The Cultures

Explores the conflict between indigenous peoples and Spanish expeditions in the Caribbean and the south.eastern U.S. As native nations defy a plundering advance by outsiders, they are subject to two unconquerable weapons: muskets and disease. The film also speaks of the death of thousands.

Episode 4: Invasion Of The Coast

As more foreigners arrive in america, tensions rise as native peoples lives are impacted. At Jamestown, the story of the powhatan princess, Pocahontas, unfolds. Thanksgiving at Plymouth leads to the bloodiest of colonial indian wars in 1675.